Bruk av antidepressive midler og antipsykotika er ikke uvanlig ved akutte korsryggssmerter, til tross for det ikke finnes dokumentert effekt av disse på smerter eller sykdomsforløp.Det at CBD ikke har en euforiserende bivirkning gjør den også spesielt interessant med tanke på smertebehandling. Det er foreløpig likevel vanskelig å finne studi
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